To get to Domodossola from Florence you can take a flight from Florence Airport, Peretola, which is the closest airport to Florence, and arrive at Lugano Airport, the airport the best serves Domodossola. The average price for a Florence to Domodossola flight is 305€, but you can find low cost flights as well, with prices starting from 141€. Getting from Florence to Domodossola by flight takes about 3 hours on average; however, you need to consider the time to get to the airport and pass the security checks. You can count on 13 daily connections between Florence and Domodossola provided by Alitalia. Lugano Airport is the closest airport to Domodossola and is 79.4 kilometers away from the city center; you can get to Domodossola in about 2 hours thanks to airport shuttles from Lugano Airport to Domodossola.