Travel from Manfredonia to Lecce and discover this Puglia city of 81.000 inhabitants. The distance from Manfredonia to Lecce is 381 kilometers; with Wanderio you can compare the available trains and buses to get from Manfredonia to Lecce, so that you can organize your trip choosing the fastest route, the most comfortable or the cheapest one. You can choose among different choices and organize your trip according to your needs, depending on whether you are looking for the fastest, the most comfortable or perhaps the cheapest travel solution. For example, by choosing a train from Manfredonia to Lecce, you’ll get to your destination in about 4 hours on average; train ticket prices start from 22 €. Going from Manfredonia to Lecce by bus instead? Prices for your ticket start from 56 € and the bus journey takes about 13 hours on average.