Travel from Rome to Ascoli Piceno and discover this Marche city of 42.000 inhabitants. The distance from Rome to Ascoli Piceno is 227 kilometers; with Wanderio you can compare the available trains and buses to get from Rome to Ascoli Piceno, so that you can organize your trip choosing the fastest route, the most comfortable or the cheapest one. You can choose among different choices and organize your trip according to your needs, depending on whether you are looking for the fastest, the most comfortable or perhaps the cheapest travel solution. For example, by choosing a bus from Rome to Ascoli Piceno, you’ll get to your destination in about 4 hours on average; bus ticket prices start from 14 €. Going from Rome to Ascoli Piceno by train instead? Prices for your ticket start from 25 € and the train journey takes about 6 hours on average.