To get to Istanbul from Rome you can take a flight from Rome Ciampino Airport, which is the closest airport to Rome, and arrive at Istanbul Atatürk Airport, the airport the best serves Istanbul. The average price for a Rome to Istanbul flight is 298€, but you can find low cost flights as well, with prices starting from 148€. Getting from Rome to Istanbul by flight takes about 3 hours on average; however, you need to consider the time to get to the airport and pass the security checks. You can count on 63 daily connections between Rome and Istanbul provided by Egyptair, SunExpress, and Pegasus Airlines. Istanbul Atatürk Airport is the closest airport to Istanbul and is 19.6 kilometers away from the city center; you can get to Istanbul in 29 minutes thanks to airport shuttles from Istanbul Atatürk Airport to Istanbul.