Travel from Rome to Pisa and discover this Toscana city of 77.000 inhabitants. The distance from Rome to Pisa is 424 kilometers; with Wanderio you can compare the available trains, buses, and flights to get from Rome to Pisa, so that you can organize your trip choosing the fastest route, the most comfortable or the cheapest one. You can choose among different choices and organize your trip according to your needs, depending on whether you are looking for the fastest, the most comfortable or perhaps the cheapest travel solution. For example, by choosing a flight from Rome to Pisa, you’ll get to your destination in about 1 hour on average; flight ticket prices start from 35 €. Going from Rome to Pisa by train instead? Prices for your ticket start from 18 € and the train journey takes about 2 hours on average.