Acqui Terme to Mazara del Vallo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Acqui Terme and arrive at Mazara del Vallo every about 12 hours on average. If travelling with Trenitalia, you need to know the Acqui Terme to Mazara del Vallo train schedule: the first train leaves at 17:44, while the last ride is at 17:44. A Acqui Terme to Mazara del Vallo train cost about 89.2 €. But how long is the train ride from Acqui Terme to Mazara del Vallo? Your journey takes about 3 hours on average.