Acqui Terme to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Acqui Terme and arrive at Messina Centrale every about 2 hours on average. If travelling with Trenitalia, you need to know the Acqui Terme to Messina train schedule: the first train leaves at 13:34, while the last ride is at 20:49. A Acqui Terme to Messina train cost about 74.85 €. But how long is the train ride from Acqui Terme to Messina? Your journey takes about 18 hours on average.