Acqui Terme to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Acqui Terme and arrive at Niscemi every about 2 hours on average. If travelling with Trenitalia, you need to know the Acqui Terme to Niscemi train schedule: the first train leaves at 09:42, while the last ride is at 20:49. A Acqui Terme to Niscemi train cost about 119.9 €. But how long is the train ride from Acqui Terme to Niscemi? Your journey takes about 3 hours on average.