Afragola to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Casoria-Afragola, Napoli Centrale and arrive at Messina Centrale, Villa S. Giovanni, Reggio di Calabria Centrale every 60 minutes on average. If travelling with Trenitalia, you need to know the Afragola to Messina train schedule: the first train leaves at 08:15, while the last ride is at 23:53. A Afragola to Messina train cost about 50.8 €. But how long is the train ride from Afragola to Messina? Your journey takes about 6 hours on average. Trenitalia offers 2 direct trains between these two cities.