Afragola to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Casoria-Afragola and arrive at Siracusa every about 4 hours on average. If travelling with Trenitalia, you need to know the Afragola to Syracuse train schedule: the first train leaves at 08:15, while the last ride is at 21:06. A Afragola to Syracuse train cost about 57.8 €. But how long is the train ride from Afragola to Syracuse? Your journey takes about 12 hours on average.