Alessandria to Brindisi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Alessandria and arrive at Brindisi every about 2 hours on average. If travelling with Trenitalia, you need to know the Alessandria to Brindisi train schedule: the first train leaves at 05:12, while the last ride is at 21:22. A Alessandria to Brindisi train cost about 72.50 €. But how long is the train ride from Alessandria to Brindisi? Your journey takes about 11 hours on average. Trenitalia offers 2 direct trains between these two cities. Thanks to Trenitalia, offers, you can save on your trip from Alessandria to Brindisi and find low cost tickets starting from 59 €! When booking your train ticket a few weeks in advance though, you can find low cost trains from Alessandria to Brindisi with fares starting from 72.50€, saving up to 6%.