Alessandria to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Alessandria and arrive at Niscemi every about 4 hours on average. If travelling with Trenitalia, you need to know the Alessandria to Niscemi train schedule: the first train leaves at 16:16, while the last ride is at 22:59. A Alessandria to Niscemi train cost about 122.15 €. But how long is the train ride from Alessandria to Niscemi? Your journey takes about 12 hours on average.