Alpignano to Mestre trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Alpignano and arrive at Milano Porta Garibaldi every about 2 hours on average. If travelling with Trenitalia, you need to know the Alpignano to Mestre train schedule: the first train leaves at 11:55, while the last ride is at 19:55. A Alpignano to Mestre train cost about 12.25 €. But how long is the train ride from Alpignano to Mestre? Your journey takes about 3 hours on average.