Ancona to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Ancona and arrive at Palermo Centrale every about 3 hours on average. If travelling with Trenitalia, you need to know the Ancona to Palermo train schedule: the first train leaves at 07:08, while the last ride is at 15:45. A Ancona to Palermo train cost about 29.4 €. But how long is the train ride from Ancona to Palermo? Your journey takes about 17 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Ancona to Palermo and find low cost tickets starting from 65 €!