Anzio to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Villa Claudia and arrive at Niscemi every about 12 hours on average. If travelling with Trenitalia, you need to know the Anzio to Niscemi train schedule: the first train leaves at 20:23, while the last ride is at 20:23. A Anzio to Niscemi train cost about 93.45 €. But how long is the train ride from Anzio to Niscemi? Your journey takes about 20 hours on average.