Anzio to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Villa Claudia and arrive at Siracusa every about 2 hours on average. If travelling with Trenitalia, you need to know the Anzio to Syracuse train schedule: the first train leaves at 06:06, while the last ride is at 20:39. A Anzio to Syracuse train cost about 72.6 €. But how long is the train ride from Anzio to Syracuse? Your journey takes about 13 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Anzio to Syracuse and find low cost tickets starting from 51 €!