Anzio to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Villa Claudia and arrive at Siracusa every about 2 hours on average. If travelling with Trenitalia, you need to know the Anzio to Syracuse train schedule: the first train leaves at 06:06, while the last ride is at 20:39. A Anzio to Syracuse train cost about 72.6 €. But how long is the train ride from Anzio to Syracuse? Your journey takes about 13 hours on average.