Asti to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Asti and arrive at Messina Centrale every about 2 hours on average. If travelling with Trenitalia, you need to know the Asti to Messina train schedule: the first train leaves at 04:32, while the last ride is at 22:36. A Asti to Messina train cost about 78.25 €. But how long is the train ride from Asti to Messina? Your journey takes about 16 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Asti to Messina and find low cost tickets starting from 32 €!