Asti to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Asti and arrive at Niscemi every about 4 hours on average. If travelling with Trenitalia, you need to know the Asti to Niscemi train schedule: the first train leaves at 16:00, while the last ride is at 22:36. A Asti to Niscemi train cost about 123.15 €. But how long is the train ride from Asti to Niscemi? Your journey takes about 12 hours on average.