Asti to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Asti and arrive at Palermo Notarbartolo every about 2 hours on average. If travelling with Trenitalia, you need to know the Asti to Palermo train schedule: the first train leaves at 13:07, while the last ride is at 22:36. A Asti to Palermo train cost about 121.15 €. But how long is the train ride from Asti to Palermo? Your journey takes about 21 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Asti to Palermo and find low cost tickets starting from 42 €!