Asti to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Asti and arrive at Siracusa every about 2 hours on average. If travelling with Trenitalia, you need to know the Asti to Syracuse train schedule: the first train leaves at 16:00, while the last ride is at 22:36. A Asti to Syracuse train cost about 78.25 €. But how long is the train ride from Asti to Syracuse? Your journey takes about 19 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Asti to Syracuse and find low cost tickets starting from 108 €!