Avezzano to Manfredonia trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Avezzano and arrive at Manfredonia every about 12 hours on average. If travelling with Trenitalia, you need to know the Avezzano to Manfredonia train schedule: the first train leaves at 20:19, while the last ride is at 20:19. A Avezzano to Manfredonia train cost about 33.8 €. But how long is the train ride from Avezzano to Manfredonia? Your journey takes about 10 hours on average.