Brindisi to Alessandria trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Brindisi and arrive at Alessandria every 60 minutes on average. If travelling with Trenitalia, you need to know the Brindisi to Alessandria train schedule: the first train leaves at 04:00, while the last ride is at 22:38. A Brindisi to Alessandria train cost about 68.25 €. But how long is the train ride from Brindisi to Alessandria? Your journey takes about 12 hours on average. Trenitalia offers 2 direct trains between these two cities. Thanks to Trenitalia, offers, you can save on your trip from Brindisi to Alessandria and find low cost tickets starting from 49 €!