Brindisi to Caltagirone trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Brindisi and arrive at Caltagirone every about 4 hours on average. If travelling with Trenitalia, you need to know the Brindisi to Caltagirone train schedule: the first train leaves at 07:49, while the last ride is at 20:38. A Brindisi to Caltagirone train cost about 66.4 €. But how long is the train ride from Brindisi to Caltagirone? Your journey takes about 12 hours on average.