Brindisi to Florence trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Brindisi and arrive at Firenze S. M. Novella every 60 minutes on average. If travelling with Trenitalia, you need to know the Brindisi to Florence train schedule: the first train leaves at 04:00, while the last ride is at 22:55. A Brindisi to Florence train cost about 74.5 €. But how long is the train ride from Brindisi to Florence? Your journey takes about 8 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Brindisi to Florence and find low cost tickets starting from 75 €!