Brindisi to Manfredonia trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Brindisi and arrive at Manfredonia every about 4 hours on average. If travelling with Trenitalia, you need to know the Brindisi to Manfredonia train schedule: the first train leaves at 14:36, while the last ride is at 15:05. A Brindisi to Manfredonia train cost about 18.9 €. But how long is the train ride from Brindisi to Manfredonia? Your journey takes about 3 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Brindisi to Manfredonia and find low cost tickets starting from 12 €!