Brindisi to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Brindisi and arrive at Messina Centrale every about 12 hours on average. If travelling with Trenitalia, you need to know the Brindisi to Messina train schedule: the first train leaves at 06:54, while the last ride is at 06:54. A Brindisi to Messina train cost about 59.8 €. But how long is the train ride from Brindisi to Messina? Your journey takes about 13 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Brindisi to Messina and find low cost tickets starting from 47 €!