Brindisi to Milazzo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Brindisi and arrive at Milazzo every about 12 hours on average. If travelling with Trenitalia, you need to know the Brindisi to Milazzo train schedule: the first train leaves at 07:49, while the last ride is at 07:49. A Brindisi to Milazzo train cost about 65.65 €. But how long is the train ride from Brindisi to Milazzo? Your journey takes about 12 hours on average.