Brindisi to Noto trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Brindisi and arrive at Noto every about 4 hours on average. If travelling with Trenitalia, you need to know the Brindisi to Noto train schedule: the first train leaves at 07:49, while the last ride is at 20:38. A Brindisi to Noto train cost about 70.35 €. But how long is the train ride from Brindisi to Noto? Your journey takes about 23 hours on average.