Brindisi to Sienna trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Brindisi and arrive at Siena every 60 minutes on average. If travelling with Trenitalia, you need to know the Brindisi to Sienna train schedule: the first train leaves at 04:00, while the last ride is at 22:38. A Brindisi to Sienna train cost about 85.7 €. But how long is the train ride from Brindisi to Sienna? Your journey takes about 11 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Brindisi to Sienna and find low cost tickets starting from 63 €!