Brindisi to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Brindisi and arrive at Siracusa every about 12 hours on average. If travelling with Trenitalia, you need to know the Brindisi to Syracuse train schedule: the first train leaves at 07:49, while the last ride is at 07:49. A Brindisi to Syracuse train cost about 46.65 €. But how long is the train ride from Brindisi to Syracuse? Your journey takes about 15 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Brindisi to Syracuse and find low cost tickets starting from 44 €!