Caltanissetta to Desio trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Caltanissetta Centrale and arrive at Desio every about 4 hours on average. If travelling with Trenitalia, you need to know the Caltanissetta to Desio train schedule: the first train leaves at 08:05, while the last ride is at 17:30. A Caltanissetta to Desio train cost about 117.0 €. But how long is the train ride from Caltanissetta to Desio? Your journey takes about 15 hours on average.