Caltanissetta to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Caltanissetta Centrale and arrive at Siracusa every about 6 hours on average. If travelling with Trenitalia, you need to know the Caltanissetta to Syracuse train schedule: the first train leaves at 10:40, while the last ride is at 17:43. A Caltanissetta to Syracuse train cost about 10.4 €. But how long is the train ride from Caltanissetta to Syracuse? Your journey takes about 4 hours on average.