Casa Santa to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Trapani and arrive at Messina Centrale every about 2 hours on average. If travelling with Trenitalia, you need to know the Casa Santa to Messina train schedule: the first train leaves at 05:43, while the last ride is at 16:01. A Casa Santa to Messina train cost about 19.1 €. But how long is the train ride from Casa Santa to Messina? Your journey takes about 7 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Casa Santa to Messina and find low cost tickets starting from 20 €!