Casa Santa to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Trapani and arrive at Siracusa every about 12 hours on average. If travelling with Trenitalia, you need to know the Casa Santa to Syracuse train schedule: the first train leaves at 06:28, while the last ride is at 06:28. A Casa Santa to Syracuse train cost about 52.0 €. But how long is the train ride from Casa Santa to Syracuse? Your journey takes about 12 hours on average.