Casalecchio di Reno to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Casalecchio di Reno and arrive at Messina Centrale every about 2 hours on average. If travelling with Trenitalia, you need to know the Casalecchio di Reno to Messina train schedule: the first train leaves at 08:42, while the last ride is at 21:14. A Casalecchio di Reno to Messina train cost about 103.3 €. But how long is the train ride from Casalecchio di Reno to Messina? Your journey takes about 14 hours on average.