Casalnuovo di Napoli to Comiso trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Casalnuovo di Napoli and arrive at Comiso every about 12 hours on average. If travelling with Trenitalia, you need to know the Casalnuovo di Napoli to Comiso train schedule: the first train leaves at 08:56, while the last ride is at 08:56. A Casalnuovo di Napoli to Comiso train cost about 64.75 €. But how long is the train ride from Casalnuovo di Napoli to Comiso? Your journey takes about 14 hours on average.