Casalnuovo di Napoli to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Casalnuovo di Napoli and arrive at Messina Centrale every about 12 hours on average. If travelling with Trenitalia, you need to know the Casalnuovo di Napoli to Messina train schedule: the first train leaves at 21:21, while the last ride is at 21:21. A Casalnuovo di Napoli to Messina train cost about 51.0 €. But how long is the train ride from Casalnuovo di Napoli to Messina? Your journey takes about 9 hours on average.