Casalnuovo di Napoli to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Casalnuovo di Napoli and arrive at Siracusa every about 6 hours on average. If travelling with Trenitalia, you need to know the Casalnuovo di Napoli to Syracuse train schedule: the first train leaves at 09:20, while the last ride is at 21:21. A Casalnuovo di Napoli to Syracuse train cost about 38.6 €. But how long is the train ride from Casalnuovo di Napoli to Syracuse? Your journey takes about 13 hours on average.