Casarano to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Lecce and arrive at Niscemi every about 12 hours on average. If travelling with Trenitalia, you need to know the Casarano to Niscemi train schedule: the first train leaves at 22:30, while the last ride is at 22:30. A Casarano to Niscemi train cost about 138.15 €. But how long is the train ride from Casarano to Niscemi? Your journey takes about 23 hours on average.