Casarano to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Lecce and arrive at Palermo Centrale every about 12 hours on average. If travelling with Trenitalia, you need to know the Casarano to Palermo train schedule: the first train leaves at 22:30, while the last ride is at 22:30. A Casarano to Palermo train cost about 96.5 €. But how long is the train ride from Casarano to Palermo? Your journey takes about 21 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Casarano to Palermo and find low cost tickets starting from 50 €!