Cassino to Castelvetrano trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Cassino and arrive at Castelvetrano every about 4 hours on average. If travelling with Trenitalia, you need to know the Cassino to Castelvetrano train schedule: the first train leaves at 07:17, while the last ride is at 19:46. A Cassino to Castelvetrano train cost about 85.35 €. But how long is the train ride from Cassino to Castelvetrano? Your journey takes about 17 hours on average.