Cassino to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Cassino and arrive at Messina Centrale every about 2 hours on average. If travelling with Trenitalia, you need to know the Cassino to Messina train schedule: the first train leaves at 07:17, while the last ride is at 19:46. A Cassino to Messina train cost about 47.2 €. But how long is the train ride from Cassino to Messina? Your journey takes about 10 hours on average.