Cassino to Niscemi trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 1 daily rides to get from Cassino to Niscemi. Trains leave from Cassino and arrive at Niscemi every about 12 hours on average. If travelling with Trenitalia, you need to know the Cassino to Niscemi train schedule: the first train leaves at 03:38, while the last ride is at 03:38. A Cassino to Niscemi train cost about 91.05 €. But how long is the train ride from Cassino to Niscemi? Your journey takes about 18 hours on average.