Cassino to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Cassino and arrive at Niscemi every about 12 hours on average. If travelling with Trenitalia, you need to know the Cassino to Niscemi train schedule: the first train leaves at 03:38, while the last ride is at 03:38. A Cassino to Niscemi train cost about 91.05 €. But how long is the train ride from Cassino to Niscemi? Your journey takes about 18 hours on average.