Cassino to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Cassino and arrive at Palermo Notarbartolo every about 4 hours on average. If travelling with Trenitalia, you need to know the Cassino to Palermo train schedule: the first train leaves at 07:17, while the last ride is at 19:37. A Cassino to Palermo train cost about 71.2 €. But how long is the train ride from Cassino to Palermo? Your journey takes about 15 hours on average.