Cassino to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Cassino and arrive at Palermo Notarbartolo every about 4 hours on average. If travelling with Trenitalia, you need to know the Cassino to Palermo train schedule: the first train leaves at 07:17, while the last ride is at 19:37. A Cassino to Palermo train cost about 71.2 €. But how long is the train ride from Cassino to Palermo? Your journey takes about 15 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Cassino to Palermo and find low cost tickets starting from 29 €!