Castelvetrano to Comiso trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Castelvetrano and arrive at Comiso every about 6 hours on average. If travelling with Trenitalia, you need to know the Castelvetrano to Comiso train schedule: the first train leaves at 05:02, while the last ride is at 07:01. A Castelvetrano to Comiso train cost about 17.6 €. But how long is the train ride from Castelvetrano to Comiso? Your journey takes about 11 hours on average.