Castelvetrano to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Castelvetrano and arrive at Siracusa every about 3 hours on average. If travelling with Trenitalia, you need to know the Castelvetrano to Syracuse train schedule: the first train leaves at 05:02, while the last ride is at 10:54. A Castelvetrano to Syracuse train cost about 19.1 €. But how long is the train ride from Castelvetrano to Syracuse? Your journey takes about 10 hours on average.