Catania to Manfredonia trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Catania Acquicella and arrive at Manfredonia every about 12 hours on average. If travelling with Trenitalia, you need to know the Catania to Manfredonia train schedule: the first train leaves at 07:18, while the last ride is at 07:18. A Catania to Manfredonia train cost about 74.65 €. But how long is the train ride from Catania to Manfredonia? Your journey takes about 23 hours on average.