Cento to Comiso trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from S. Pietro in Casale and arrive at Comiso every about 4 hours on average. If travelling with Trenitalia, you need to know the Cento to Comiso train schedule: the first train leaves at 09:57, while the last ride is at 18:55. A Cento to Comiso train cost about 111.45 €. But how long is the train ride from Cento to Comiso? Your journey takes about 14 hours on average.