Cento to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from S. Pietro in Casale and arrive at Niscemi every about 6 hours on average. If travelling with Trenitalia, you need to know the Cento to Niscemi train schedule: the first train leaves at 00:09, while the last ride is at 18:52. A Cento to Niscemi train cost about 163.55 €. But how long is the train ride from Cento to Niscemi? Your journey takes about 22 hours on average.