Cento to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from S. Pietro in Casale and arrive at Siracusa every about 2 hours on average. If travelling with Trenitalia, you need to know the Cento to Syracuse train schedule: the first train leaves at 00:09, while the last ride is at 19:23. A Cento to Syracuse train cost about 118.95 €. But how long is the train ride from Cento to Syracuse? Your journey takes about 16 hours on average.